In US coin collecting (numismatism if you have a fancy edu-ma-ca-shun), "alignment" or "coin alignment" means the coin is set head to foot, like a monetary coin. That is if you hold the top and bottom, and spin it 180 degrees, the flipside should appear upside down (or in rare cases, just tilted at an angle). Silver strikes tend be printed head to head, not head to foot. Whether or not the aligned strike is more or less valuable depends entirely on the amount of them produced, distributed, and available. Some errors (like the Sam's Town $20 mispelled "limtied" coyote) are actually slightly less valuable than the correct version. Usually due to supply and demand. A price guide will help you decide if that strike is more valuable.

Hope this helps.

Pete